Multi-parametric MRI characterization of enzymatically degraded articular cartilage.

  title={Multi-parametric MRI characterization of enzymatically degraded articular cartilage.},
  author={Mikko J Nissi and Elli-Noora Salo and Virpi Tiitu and Timo Liimatainen and Shalom Michaeli and Silvia Mangia and Jutta Maria Ellermann and Miika Nieminen},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  volume={34 7},
Several laboratory and rotating frame quantitative MRI parameters were evaluated and compared for detection of changes in articular cartilage following selective enzymatic digestion. Bovine osteochondral specimens were subjected to 44 h incubation in control medium or in collagenase or chondroitinase ABC to induce superficial collagen or proteoglycan (glycosaminoglycan) alterations. The samples were scanned at 9.4 T for T1 , T1 Gd (dGEMRIC), T2 , adiabatic T1 ρ , adiabatic T2 ρ , continuous… CONTINUE READING