Multi-parameter measurement of the permeability transition pore opening in isolated mouse heart mitochondria.


The mitochondrial permeability transition pore (mtPTP) is a non specific channel that forms in the inner mitochondrial membrane to transport solutes with a molecular mass smaller than 1.5 kDa. Although the definitive molecular identity of the pore is still under debate, proteins such as cyclophilin D, VDAC and ANT contribute to mtPTP formation. While the… (More)
DOI: 10.3791/4131