Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses.

@article{Kharel2007MultioxygenaseCO,
  title={Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses.},
  author={M. Kharel and Lili Zhu and Tao Liu and J. Rohr},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 13},
  pages={
          3780-1
        }
}
The biosyntheses of the gilvocarcins (e.g., gilvocarcin V, 6, scheme 1), and jadomycins (e.g., jadomycin B, 4) are both dominated by oxidative rearrangement cascades that lead from simple polyketide-derived angucyclinones to the unique tetracyclic benzo[d]naphtho[1,2-b]pyran-6-one and pentacyclic benz[b]oxazolophenanthridine backbones, respectively, which are typical and essential for these anticancer antibiotics. Previous work showed that UWM6 (1a) and prejadomycin (= 2,3-dehydro-UWM6, 2a) or… Expand
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