Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas

@inproceedings{CastroVega2015MultiomicsAD,
  title={Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas},
  author={Luis-Jaime Castro-Vega and Eric Letouz{\'e} and Nelly Burnichon and Alexandre Buffet and Disderot Ph and Emmanuel Khalifa and C{\'e}line Loriot and Nabila Elarouci and Aur{\'e}lie Morin and M{\'e}lanie Menara and Charlotte Lepoutre-Lussey and C{\'e}cile Badoual and Mathilde Sibony and B. Dousset and Rossella Lib{\'e} and Frank Zinzindohou{\'e} and Pierre François Plouin and J{\'e}r{\^o}me Bertherat and Laurence Amar and A deReyni{\`e}s and Judith Favier and Anne-Paule Gimenez-Roqueplo},
  booktitle={Nature communications},
  year={2015}
}
  • Luis-Jaime Castro-Vega, Eric Letouzé, +19 authors Anne-Paule Gimenez-Roqueplo
  • Published in Nature communications 2015
  • DOI:10.1038/ncomms7044
Pheochromocytomas and paragangliomas (PCCs/PGLs) are neural crest-derived tumours with a very strong genetic component. Here we report the first integrated genomic examination of a large collection of PCC/PGL. SNP array analysis reveals distinct copy-number patterns associated with genetic background. Whole-exome sequencing shows a low mutation rate of 0.3 mutations per megabase, with few recurrent somatic mutations in genes not previously associated with PCC/PGL. DNA methylation arrays and… CONTINUE READING
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