Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity.

@article{Rowlands2014MultiomicIN,
  title={Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity.},
  author={David Stephen Rowlands and Rachel A Page and William R. Sukala and Mamta Giri and Svetlana D Ghimbovschi and Irum Hayat and Birinder S Cheema and Isabelle Lys and Murray J. Leikis and Phillip W Sheard and St John Wakefield and Bernhard H. Breier and Yetrib Hathout and Kristy Brown and Ramya L Marathi and Funda E Orkunoglu-Suer and Joseph M. Devaney and Benjamin Leiken and Gina M. Many and Jeremy D Krebs and Will G Hopkins and Eric P. Hoffman},
  journal={Physiological genomics},
  year={2014},
  volume={46 20},
  pages={747-65}
}
Epigenomic regulation of the transcriptome by DNA methylation and posttranscriptional gene silencing by miRNAs are potential environmental modulators of skeletal muscle plasticity to chronic exercise in healthy and diseased populations. We utilized transcriptome networks to connect exercise-induced differential methylation and miRNA with functional skeletal muscle plasticity. Biopsies of the vastus lateralis were collected from middle-aged Polynesian men and women with morbid obesity (44 kg/m(2… CONTINUE READING

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