Multi-nucleated giant cell formation from human cord blood monocytes in vitro, in comparison with adult peripheral blood monocytes.

@article{Kondo2009MultinucleatedGC,
  title={Multi-nucleated giant cell formation from human cord blood monocytes in vitro, in comparison with adult peripheral blood monocytes.},
  author={Yoshitaka Kondo and Kenzo Yasui and Masato Yashiro and Mitsuru Tsuge and Norihiro Kotani and Tatsuya Morishima},
  journal={Clinical and experimental immunology},
  year={2009},
  volume={158 1},
  pages={84-90}
}
Multi-nucleated giant cells (MGCs; Langhans-type cell), formed from macrophage fusion, are recognized as a hallmark histological feature in chronic inflammation. However, their precise pathological role is still poorly understood, especially for microorganism pathogens in the neonatal immune system, which are capable of surviving intracellularly in phagocytes. To conduct a partial evaluation of the monocyte function of neonates, we investigated the ability of human cord blood monocytes to form… CONTINUE READING
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