Multi-locus sequence typing: a tool for global epidemiology.

@article{Urwin2003MultilocusST,
  title={Multi-locus sequence typing: a tool for global epidemiology.},
  author={Rachel Urwin and Martin C J Maiden},
  journal={Trends in microbiology},
  year={2003},
  volume={11 10},
  pages={479-87}
}
The characterization of pathogenic isolates plays a pivotal role in the epidemiology of infectious diseases, generating the information necessary for identifying, tracking, and intervening against disease outbreaks. In 1998 multi-locus sequence typing (MLST) was proposed as a nucleotide sequence-based approach that could be applied to many bacterial pathogens. It combined developments in high-throughput sequencing and bioinformatics with established population genetics techniques to provide a… CONTINUE READING
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