Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

@inproceedings{Wagner2017MultilevelSO,
  title={Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells},
  author={Renate Wagner and Gerald St{\"u}biger and Daniel Veigel and Michael Wuczkowski and Peter Lanzerstorfer and Julian Weghuber and Emmanouil Karteris and Karin Nowikovsky and Nastasia Wilfinger-Lutz and Christian F Singer and Ramon Colomer and Bellinda Benham{\'u} and Mar{\'i}a L. L{\'o}pez-Rodr{\'i}guez and Peter Valent and Thomas W. Grunt},
  booktitle={Oncotarget},
  year={2017}
}
Receptor-PI3K-mTORC1 signaling and fatty acid synthase (FASN)-regulated lipid biosynthesis harbor numerous drug targets and are molecularly connected. We hypothesize that unraveling the mechanisms of pathway cross-talk will be useful for designing novel co-targeting strategies for ovarian cancer (OC). The impact of receptor-PI3K-mTORC1 onto FASN is already well-characterized. However, reverse actions-from FASN towards receptor-PI3K-mTORC1-are still elusive. We show that FASN-blockade impairs… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Signal transduction through lipid second messengers.

  • Current opinion in cell biology
  • 1996
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells.

  • Biochemical and biophysical research communications
  • 2009
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Sheets: Ovary Cancer

SEER Stat Fac
  • [online]. Available from: http://seer.cancer.gov/statfacts/html/ovary.html. Retrieved on January 19,
  • 2016
VIEW 1 EXCERPT