Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response

@inproceedings{Rand2012MultilayeredSA,
  title={Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response},
  author={Ulfert Rand and Melanie Rinas and Johannes Schwerk and Gesa N{\"o}hren and Melanie Linnes and Andrea Kr{\"o}ger and Michael Flossdorf and Krist{\'o}f K{\'a}ly-Kullai and Hansjoerg Hauser and Thomas H{\"o}fer and Mario K{\"o}ster},
  booktitle={Molecular systems biology},
  year={2012}
}
The cellular recognition of viruses evokes the secretion of type-I interferons (IFNs) that induce an antiviral protective state. By live-cell imaging, we show that key steps of virus-induced signal transduction, IFN-β expression, and induction of IFN-stimulated genes (ISGs) are stochastic events in individual cells. The heterogeneity in IFN production is of cellular-and not viral-origin, and temporal unpredictability of IFN-β expression is largely due to cell-intrinsic noise generated both… CONTINUE READING
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