Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.

@article{Akita2009MultilayeredNF,
  title={Multi-layered nanoparticles for penetrating the endosome and nuclear membrane via a step-wise membrane fusion process.},
  author={Hidetaka Akita and Asako Kudo and Arisa Minoura and Masaya Yamaguti and Ikramy A Khalil and Rumiko Moriguchi and Tomoya Masuda and Radostin Danev and Kuniaki Nagayama and Kentaro Kogure and Hideyoshi Harashima},
  journal={Biomaterials},
  year={2009},
  volume={30 15},
  pages={2940-9}
}
Efficient targeting of DNA to the nucleus is a prerequisite for effective gene therapy. The gene-delivery vehicle must penetrate through the plasma membrane, and the DNA-impermeable double-membraned nuclear envelope, and deposit its DNA cargo in a form ready for transcription. Here we introduce a concept for overcoming intracellular membrane barriers that involves step-wise membrane fusion. To achieve this, a nanotechnology was developed that creates a multi-layered nanoparticle, which we refer… CONTINUE READING
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