Multi-ion pore behaviour in the CFTR chloride channel

  title={Multi-ion pore behaviour in the CFTR chloride channel},
  author={Joseph A. Tabcharani and Johanna M Rommens and Yue-xian Hou and Xiu-bao Chang and Lap-chee Tsui and John R. Riordan and John W. Hanrahan},
CYSTIC fibrosis transmembrane conductance regulator (CFTR) is a non-rectifying, low-conductance channel1,2 regulated by ATP3 and phosphorylation4, which mediates apical chloride conductance in secretory epithelia5,6 and malfunctions in cystic fibrosis (CF)7,8. Mutations at Lys 335 and Arg 347 in the sixth predicted transmembrane helix of CFTR alter its halide selectivity in whole-cell studies9 and its single channel conductance10, but the physical basis of these alterations is unknown and… CONTINUE READING

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