Multi-hormonal weight loss combinations in diet-induced obese rats: therapeutic potential of cholecystokinin?

@article{Trevaskis2010MultihormonalWL,
  title={Multi-hormonal weight loss combinations in diet-induced obese rats: therapeutic potential of cholecystokinin?},
  author={James L Trevaskis and Victoria F Turek and Peter S Griffin and Carrie Wittmer and David G. Parkes and Jonathan David Roth},
  journal={Physiology & behavior},
  year={2010},
  volume={100 2},
  pages={187-95}
}
Cholecystokinin (CCK) acutely synergizes with amylin to suppress food intake in lean mice. To extend on these findings, the present studies sought to identify neural correlates for the interaction of amylin and CCK, as well as further understand the therapeutic potential of CCK-based combinations in obesity. First, c-Fos activation was assessed in various brain nuclei after a single intraperitoneal injection of amylin (5microg/kg) and/or CCK (5microg/kg). Amylin and CCK additively increased c… CONTINUE READING
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