Multi-generational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.

  title={Multi-generational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.},
  author={Y. Sun and Q. Wang and Y. Zhang and Mengyuan Geng and Yujuan Wei and Y. Liu and S. Liu and R. Petersen and Junqiu Yue and K. Huang and L. Zheng},
  journal={Journal of hepatology},
  • Y. Sun, Q. Wang, +8 authors L. Zheng
  • Published 2020
  • Biology, Medicine
  • Journal of hepatology
  • BACKGROUND & AIMS The global obesity epidemic is threatening human health. How maternal obesity affects the incidence of offspring hepatocellular carcinoma (HCC) remains unknown. We investigated this association and the underlying mechanism. METHODS Diethylnitrosamine (DEN) was applied to induce HCC in a high-fat-diet (HFD) induced multi-generational obesity model. RNA-sequencing was performed to identify the genes and miRNAs that altered over generations. The role of miR-27a-3p-Acsl1/Aldh2… CONTINUE READING
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