Multi-factorial role of GnRH-I and GnRH-II in the human ovary

@article{Leung2003MultifactorialRO,
  title={Multi-factorial role of GnRH-I and GnRH-II in the human ovary},
  author={Peter C. K. Leung and Chi Keung Cheng and Xiao-ming Zhu},
  journal={Molecular and Cellular Endocrinology},
  year={2003},
  volume={202},
  pages={145-153}
}
View on Elsevier
doi.org
100 Citations
Highly Influential Citations
3
Background Citations
30
Methods Citations
1
Results Citations
1

100 Citations

Citation Type

Citation Type

GnRH and GnRH receptors in the pathophysiology of the human female reproductive system.
TLDR
Increasing knowledge about the regulation of GnRH pulsatile release, as well as the therapeutic use of its analogues, offers interesting new perspectives in the diagnosis, treatment and outcome of female reproductive disorders, including tumoral and iatrogenic diseases.
Gonadotropin-Releasing Hormone in the Ovary
TLDR
The biology of the GnRH/GnRHR system in humans, the potential roles of GnRH, and the direct effects of Gn RH analogues in ovarian cells are discussed.
The mammalian type II gonadotropin-releasing hormone receptor : cloning, distribution and role in gonadotropin gene expression
TLDR
It is demonstrated for the first time that GnRH-1 may affect gonadotropin subunit gene expression via GnR HR-II in addition to GnRHR-I, and that Gn RH-2 also has the ability to regulate gonadotropic subunit genes expression via both receptors.
Gonadotropin-releasing hormone (GnRH) and its natural analogues: a review.
GnRH in the Human Female Reproductive Axis.
Expression dynamics of gonadotropin-releasing hormone-I and its mutual regulation with luteinizing hormone in chicken ovary and follicles.
GnRH in non-hypothalamic reproductive tissues.
Localization of gonadotrophin-releasing hormone I, bradykinin and their receptors in the ovaries of non-mammalian vertebrates.
TLDR
The results suggest the possibility of GnRH I and bradykinin as important regulators of follicular development and vitellogenesis in the vertebrate ovary.
Immunohistochemical localization of GnRH and RFamide-related peptide-3 in the ovaries of mice during the estrous cycle
TLDR
It is hypothesized that interaction between GnRH I-RFRP-3 neuropeptides may be involved in the regulation of follicular development and atresia.
Gonadotropin releasing hormone analogue (GnRHa) alters the expression and activation of Smad in human endometrial epithelial and stromal cells
TLDR
The results indicate that GnRH acts directly on the endometrial cells altering the expression and activation of Smads, a mechanism that could lead to interruption of TGF-beta receptor signaling mediated through this pathway in theendometrium.
...
...

References

SHOWING 1-10 OF 79 REFERENCES
Regulation of Gonadotropin-Releasing Hormone and Its Receptor Gene Expression by 17β-Estradiol in Cultured Human Granulosa-Luteal Cells.
TLDR
The role of 17β-estradiol (E2) in regulating GnRH and GnRH-R messenger RNA (mRNA) from human granulosa-luteal cells (hGLCs) is investigated and sequence analysis revealed that the ovarian Gn RH-R mRNA is identical to its pituitary counterpart.
Gonadotropin-releasing hormone as a paracrine hormone and neurotransmitter in extra-pituitary sites.
Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid in human granulosa-luteal cells.
TLDR
GnRH-II may have biological effects similar to those of GnRH-I but is under differential hormonal regulation in the human ovary, suggesting that it may exert their antigonadotropic effect by down-regulating gonadotropin receptors.
Role of Gonadotropin-Releasing Hormone as an Autocrine Growth Factor in Human Ovarian Surface Epithelium1.
TLDR
Novel evidence is provided that GnRH may have antiproliferative effects in human ovarian surface epithelial cells and GnRH and its receptor have sequences identical to those found in the hypothalamus and pituitary, respectively.
Second gene for gonadotropin-releasing hormone in humans.
TLDR
Molecular phylogenetic analysis shows that this second GnRH-II gene is likely the result of a duplication before the appearance of vertebrates, and predicts the existence of a third GnRH form in humans and other vertebrates.
Gonadotropin-releasing hormone as a modulator of ovarian function.
Gonadotropin-releasing hormone and its analogs.
TLDR
The physiologic and pharmacologic principles underlying the advances produced by these agents, the mechanism of action of GnRH and its analogues at the cellular level, and the individual therapeutic applications to which these analogues have been applied are examined.
A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates.
TLDR
It is demonstrated that a second receptor (type II) gene is present in the human genome, and the cloning and characterization of its cDNA from monkeys are reported, the first report of a GnRH type II receptor in mammals.
Regional expression of mRNA encoding a second form of gonadotropin-releasing hormone in the macaque brain.
TLDR
Cl cloning of a GnRH-II cDNA from the rhesus macaque is reported and it is shown for the first time by in situ hybridization that Gn RH-II mRNA is expressed in the primate midbrain, hippocampus and discrete nuclei of the hypothalamus, including the supraoptic, paraventricular, suprachiasmatic and arcuate.
Gonadotropin-releasing hormone activates mitogen-activated protein kinase in human ovarian and placental cells
...
...