Multi-drug resistance protein (Mrp) 3 may be involved in resveratrol protection against methotrexate-induced testicular damage.

@article{ElSheikh2014MultidrugRP,
  title={Multi-drug resistance protein (Mrp) 3 may be involved in resveratrol protection against methotrexate-induced testicular damage.},
  author={Azza A K El-Sheikh and Mohamed A. Morsy and Abdulla Y. Al-Taher},
  journal={Life sciences},
  year={2014},
  volume={119 1-2},
  pages={
          40-6
        }
}
AIMS To investigate the effect of resveratrol (RES) on methotrexate (MTX)-induced testicular damage. MAIN METHODS RES (10mg/kg/day) was given for 8 days orally and MTX (20mg/kg i.p.) was given at day 4 of the experiment, with or without RES in rat. KEY FINDINGS MTX decreased serum testosterone, induced histopathological testicular damage, and increased testicular tumor necrosis factor-α level and expression of nuclear factor-κB and cyclooxygenase-2. In MTX/RES group, significant reversal of… Expand
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References

SHOWING 1-10 OF 65 REFERENCES
Protective mechanisms of coenzyme-Q10 may involve up-regulation of testicular P-glycoprotein in doxorubicin-induced toxicity.
TLDR
CoQ10 protects against DOX-induced testicular toxicity in rats via ameliorating oxidative stress, reducing apoptosis and up-regulating testicular P-gp as a novel mechanism for gonadal protection. Expand
Effects of Resveratrol on Methotrexate-Induced Testicular Damage in Rats
TLDR
The results indicate that RES has protective effects against MTX-induced testis damage at the biochemical, histopathological, and apoptotic levels. Expand
Resveratrol protects against methotrexate-induced hepatic injury in rats.
  • T. Tunali-Akbay, Ozer Sehirli, F. Ercan, G. Şener
  • Chemistry, Medicine
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2010
TLDR
The present study showed that resveratrol protects against methotrexate-induced hepatic injury and may be of therapeutic potential in alleviating the systemic side effects of chemotherapeutics. Expand
Antiapoptotic and antioxidant effects of beta-carotene against methotrexate-induced testicular injury.
OBJECTIVE To investigate the effect of beta-carotene against testicular injury induced by methotrexate (MTX). DESIGN Experimental study. SETTING Animal and histology laboratory at InonuExpand
Protective effect of peroxisome proliferator activator receptor (PPAR)-α and -γ ligands against methotrexate-induced nephrotoxicity
TLDR
At indicated dosage, PPar-γ ligand; PIO shows better improvement of MTX-induced nephrotoxicity compared to PPAR-αligand; FEN due to differential effect on TNF-α/NF-κB inflammatory pathway. Expand
Resveratrol Reverses Cadmium Chloride-induced Testicular Damage and Subfertility by Downregulating p53 and Bax and Upregulating Gonadotropins and Bcl-2 gene Expression
TLDR
Administration of RES before or after cadmium chloride in rats improved semen parameters including count, motility, daily sperm production and morphology, increased serum concentrations of gonadotropins and testosterone, decreased testicular lipid peroxidation and increased SOD activity. Expand
Curcumin Ameliorates Methotrexate-Induced Nephrotoxicity in Rats
TLDR
Curcumin protected rats from methotrexate nephrotoxicity, at least in part, through its antioxidant and anti-inflammatory activities. Expand
Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice
TLDR
Erdosteine could effectively protect the testes in methotrexate-induced toxicity in mice, and the levels of total antioxidant capacity and total oxidative stress, and myeloperoxidase activity in the metotrexate group were higher than the control group (p<0.05). Expand
Protective effects of thymoquinone against methotrexate-induced testicular injury
TLDR
It is suggested that thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent. Expand
Intestinal Breast Cancer Resistance Protein (BCRP)/Bcrp1 and Multidrug Resistance Protein 3 (MRP3)/Mrp3 Are Involved in the Pharmacokinetics of Resveratrol
The phytoestrogen resveratrol has putative health-promoting effects and is present in several dietary constituents. Resveratrol is metabolized extensively in the gut epithelium, resulting in theExpand
...
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3
4
5
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