Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements.

@article{Fredericks2007MultidrugRG,
  title={Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements.},
  author={Salim Fredericks and Anamaria Jorga and I Macphee and Sandrine Reboux and Elizabeth Shiferaw and Michelle Moreton and Nicholas D. Carter and David W Holt and Atholl Johnston},
  journal={Clinical transplantation},
  year={2007},
  volume={21 2},
  pages={
          252-7
        }
}
The intestinal efflux pump P-glycoprotein (P-gp), the product of the multi-drug resistance-1 (MDR-1) gene, significantly influences the pharmacokinetics of several drugs. Ciclosporin is a substrate for P-gp and is metabolized by cytochrome P450 (CYP) 3A enzymes. P-gp activity is affected by several known single nucleotide polymorphisms (SNPs) and haplotypes. MDR-1 genotypes of SNPs C1236T, G2677T/A and C3435T, as well as haplotypes C-G-C and T-T-T and CYP3A5*1 genotype (predictive of CYP3A5… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Influence of the MDR1 haplotype and CYP3A5 genotypes on cyclosporine blood level in Chinese renal transplant recipients.

  • Xenobiotica; the fate of foreign compounds in biological systems
  • 2009
VIEW 1 EXCERPT
CITES BACKGROUND
HIGHLY INFLUENCED

The role of genetics in drug dosing

  • Pediatric Nephrology
  • 2012
VIEW 1 EXCERPT
CITES BACKGROUND