Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis

@inproceedings{Faehnle2017MultidomainUB,
  title={Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis},
  author={Christopher R. Faehnle and Jack G. Walleshauser and Leemor Joshua-Tor},
  booktitle={Nature Structural &Molecular Biology},
  year={2017}
}
The uridyl transferases TUT4 and TUT7 (collectively called TUT4(7)) switch between two modes of activity, either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU). Lin28 modulates the switch via recruitment of TUT4(7) to the precursor pre-let-7 in stem cells and human cancers. We found that TUT4(7) utilize two multidomain functional modules during the switch from monoU to oligoU. The catalytic module (CM) is essential for both activities, while the Lin28… CONTINUE READING
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