Multi-domain interventions for the prevention of dementia and cognitive decline.

@article{Hafdi2021MultidomainIF,
  title={Multi-domain interventions for the prevention of dementia and cognitive decline.},
  author={Melanie Hafdi and Marieke Peternella Hoevenaar-Blom and Edo Richard},
  journal={The Cochrane database of systematic reviews},
  year={2021},
  volume={11},
  pages={
          CD013572
        }
}
BACKGROUND Dementia is a worldwide concern. Its global prevalence is increasing. Currently, no effective medical treatment exists to cure or to delay the onset of cognitive decline or dementia. Up to 40% of dementia is attributable to potentially modifiable risk factors, which has led to the notion that targeting these risk factors might reduce the incidence of cognitive decline and dementia. Since sporadic dementia is a multifactorial condition, thought to derive from multiple causes and risk… 
1 Citations
Embodied Prevention
Evidence-based recommendations for lifestyles to promote healthy cognitive aging (exercise, education, non-smoking, balanced diet, etc.) root in reductionistic studies of mostly physical measurable

References

SHOWING 1-10 OF 123 REFERENCES
Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer’s Disease, and Dementia: From FINGER to World-Wide FINGERS
TLDR
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) is the first large, long-term RCT to demonstrate that a multidomain lifestyle-based intervention ameliorating vascular and lifestyle-related risk factors can preserve cognitive functioning and reduce the risk of cognitive decline among older adults at increased risk of dementia.
Physical Activity Interventions in Preventing Cognitive Decline and Alzheimer-Type Dementia
TLDR
This systematic review reports a synthesis of the evidence assessing the effectiveness of physical activity interventions in slowing cognitive decline and delaying the onset of cognitive impairment and dementia in adults without diagnosed cognitive impairments.
A Population Perspective on Prevention of Dementia
TLDR
An overview of available evidence for the potential for dementia prevention is given and methodological issues that might complicate the development of effective prevention interventions are discussed, to explore the opportunities and challenges for future dementia prevention research.
Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia.
TLDR
No convincing evidence from the trials identified that blood pressure lowering in late-life prevents the development of dementia or cognitive impairment in hypertensive patients with no apparent prior cerebrovascular disease is identified.
Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia.
TLDR
This updated systematic review investigated the effect on cognitive function of the type of treatment and level of metabolic control in people with Type 2 diabetes and found that the intensity of glycaemic control may have little or no effect on all-cause mortality.
Multidomain Lifestyle Intervention Strategies for the Delay of Cognitive Impairment in Healthy Aging
TLDR
The results of the identified original studies reveal that multidomain lifestyle interventions generate significant effects and there is a call for the implementation of effective lifestyle prevention programs, which would involve goal-setting and would focus on the prevention of crucial risk factors threatening the target group of elderly people.
Prevention of Dementia by Intensive Vascular Care (PreDIVA): A Cluster-randomized Trial in Progress
TLDR
In this older age group, the very high percentage of elderly subjects with cardiovascular risk factors illustrates the large window of opportunity for therapies directed to lower the cardiovascular risk and potentially also the risk for dementia.
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment.
TLDR
The primary efficacy outcomes were the incidence of dementia and scores on measures of overall cognitive function and the risk of bias of included studies using the Cochrane 'Risk of bias' assessment tool.
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