Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF

  title={Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF},
  author={Cameron David Mackereth and Tobias Madl and Sophie Bonnal and Bernd Simon and Katia Zanier and Alexander Gasch and Vladimir Rybin and Juan Valc{\'a}rcel and Michael Sattler},
Many cellular functions involve multi-domain proteins, which are composed of structurally independent modules connected by flexible linkers. Although it is often well understood how a given domain recognizes a cognate oligonucleotide or peptide motif, the dynamic interaction of multiple domains in the recognition of these ligands remains to be characterized. Here we have studied the molecular mechanisms of the recognition of the 3′-splice-site-associated polypyrimidine tract RNA by the large… CONTINUE READING
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