Multi-detection of corticosteroids in sports doping and veterinary control using high-resolution liquid chromatography/time-of-flight mass spectrometry.

@article{Touber2007MultidetectionOC,
  title={Multi-detection of corticosteroids in sports doping and veterinary control using high-resolution liquid chromatography/time-of-flight mass spectrometry.},
  author={Manja E Touber and Marcel C van Engelen and Costas Georgakopoulus and Johannes A van Rhijn and Michel W F Nielen},
  journal={Analytica chimica acta},
  year={2007},
  volume={586 1-2},
  pages={137-46}
}
A liquid chromatography/time-of-flight mass spectrometry (LC/TOFMS) method was developed using the latest high-resolution LC column technology, the ultra performance liquid chromatography (UPLC), and electrospray ionization (ESI) in the positive ion mode. Gradient UPLC separation conditions were optimized for a group of 22 analytes comprising 17 glucocorticosteroids, specific designer steroids such as tetrahydrogestrinone (THG) and specific beta2-agonists such as formoterol. The UPLC/TOFMS… CONTINUE READING