Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively

@article{Takagi1995MulticolonySA,
  title={Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively},
  author={Minoru Takagi and Tomoko Hara and Masatoshi Ichihara and Kiyoshi Takatsu and Atsushi Miyajima},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={889 - 899}
}
The interleukin 3 (IL-3), IL-5, and granulocyte/macrophage colony-stimulating factor receptors consist of a cytokine-specific alpha subunit and the common beta subunit. Whereas IL-3 stimulates various lineages of hematopoietic cells, including multipotential progenitors, IL-5 acts mainly as an eosinophil lineage-specific factor. To investigate whether the lineage specificity of IL-5 is due to restricted expression of the IL-5 receptor alpha subunit (IL-5R alpha), we generated transgenic mice… CONTINUE READING
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Possible role of stem cell factor as a serum factor : monoclonal antic - kit antibody abrogates interleukin - 6 - dependent colony growth in serum - containing culture

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