Multi-chaperone complexes regulate the folding of interferon-gamma in the endoplasmic reticulum.

@article{Vandenbroeck2006MultichaperoneCR,
  title={Multi-chaperone complexes regulate the folding of interferon-gamma in the endoplasmic reticulum.},
  author={Koen Vandenbroeck and Erik Martens and Iraide Alloza},
  journal={Cytokine},
  year={2006},
  volume={33 5},
  pages={264-73}
}
The quality control mechanisms directing the folding of cytokines in the endoplasmic reticulum (ER) are poorly understood. We have investigated ER chaperone usage by the cytokine interferon-gamma (IFN-gamma). ATP-depletion or inhibition of N-glycosylation was found to cause IFN-gamma to accumulate into detergent-insoluble aggregates in the ER. Six… CONTINUE READING