Multi-bit information storage by multisite phosphorylation

  title={Multi-bit information storage by multisite phosphorylation},
  author={Matthew W Thomson and Jeremy Gunawardena},
Cells store information in DNA and in stable programs of gene xpression, which thereby implement forms of long-term cellular m e ory. Cells must also possess short-term forms of information storage, implemented posttranslationally, to transduce and interpret external sign als. CaMKII, for instance, is thought to implement a one-bit (bistable) shortterm memory required for learning at post-synaptic densities. Here we sho w by mathematical analysis that multisite protein phosphorylation, which is… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 58 references

The molecular ba sis of CaMKII function in synaptic and behavioural memory

  • J. E. Lisman, H. Schulman, H. Kline
  • Nat. Rev. Neurosci., 3:175–90,
  • 2002
Highly Influential
7 Excerpts

Differential Equations, Dynamical Systems and Linear Algebra

  • M. W. Hirsch, S. Smale
  • Pure and Applied Mathematics. Academic Press, San…
  • 1974
Highly Influential
4 Excerpts

Descartes’ Rul e of Signs revisited

  • B. Anderson, J. Jackson, M. Sitharam
  • Amer. Math. Monthly, 105:447–451,
  • 1998
Highly Influential
3 Excerpts

A proof of Sturm’s Theorem

  • M. F. Smiley
  • Amer. Math. Monthly, 49:185–6,
  • 1942
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…