Multi-bit information storage by multisite phosphorylation

@inproceedings{Thomson2007MultibitIS,
  title={Multi-bit information storage by multisite phosphorylation},
  author={Matthew W Thomson and Jeremy Gunawardena},
  year={2007}
}
Cells store information in DNA and in stable programs of gene xpression, which thereby implement forms of long-term cellular m e ory. Cells must also possess short-term forms of information storage, implemented posttranslationally, to transduce and interpret external sign als. CaMKII, for instance, is thought to implement a one-bit (bistable) shortterm memory required for learning at post-synaptic densities. Here we sho w by mathematical analysis that multisite protein phosphorylation, which is… CONTINUE READING

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