Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell

@article{Krause2001MultiOrganME,
  title={Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell},
  author={D. Krause and N. Theise and M. Collector and O. Henegariu and Sonya J Hwang and Rebekah Gardner and S. Neutzel and S. Sharkis},
  journal={Cell},
  year={2001},
  volume={105},
  pages={369-377}
}
Purification of rare hematopoietic stem cell(s) (HSC) to homogeneity is required to study their self-renewal, differentiation, phenotype, and homing. Long-term repopulation (LTR) of irradiated hosts and serial transplantation to secondary hosts represent the gold standard for demonstrating self-renewal and differentiation, the defining properties of HSC. We show that rare cells that home to bone marrow can LTR primary and secondary recipients. During the homing, CD34 and SCA-1 expression… Expand

Paper Mentions

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