Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

@article{Xie2011MultiInputRL,
  title={Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells},
  author={Zhen Xie and Liliana Wroblewska and Laura Prochazka and Ron Weiss and Yaakov Benenson},
  journal={Science},
  year={2011},
  volume={333},
  pages={1307 - 1311}
}
A synthetic biomolecular circuit identifies abnormal cell states by the integration of multiple endogenous microRNA inputs. Engineered biological systems that integrate multi-input sensing, sophisticated information processing, and precisely regulated actuation in living cells could be useful in a variety of applications. For example, anticancer therapies could be engineered to detect and respond to complex cellular conditions in individual cells with high specificity. Here, we show a scalable… 
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