Multi High-Throughput Approach for Highly Selective Identification of Vaccine Candidates: the Group A Streptococcus Case*

@inproceedings{Bensi2012MultiHA,
  title={Multi High-Throughput Approach for Highly Selective Identification of Vaccine Candidates: the Group A Streptococcus Case*},
  author={Giuliano Bensi and Marirosa Mora and Giovanna Tuscano and Massimiliano Biagini and Emiliano Chiarot and Mauro Bombaci and Sabrina Capo and Fabiana Falugi and Andrea Guido Oreste Manetti and Paolo Donato and Erwin Frans Swennen and Marilena Gallotta and Manuela Garibaldi and Vittoria Pinto and Nico Chiappini and James M. Musser and Robert Janulczyk and Massimo Alessandro Mariani and Maria Scarselli and John L. Telford and Renata M. Grifantini and Nathalie Norais and Immaculada Margarit and Guido Grandi},
  booktitle={Molecular & cellular proteomics : MCP},
  year={2012}
}
We propose an experimental strategy for highly accurate selection of candidates for bacterial vaccines without using in vitro and/or in vivo protection assays. Starting from the observation that efficacious vaccines are constituted by conserved, surface-associated and/or secreted components, the strategy contemplates the parallel application of three high… CONTINUE READING