Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.

@article{DominguezBrauer2016MuleRT,
  title={Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation.},
  author={Carmen Dominguez-Brauer and Zhenyue Hao and Andrew J Elia and J{\'e}r{\^o}me Michel Claude Fortin and Robert Nechanitzky and Patrick M Brauer and Yu-wen Sheng and Miyeko D. Mana and Iok In Christine Chio and Jillian Haight and Aaron Pollett and Robert B. Cairns and Leanne Tworzyanski and Satoshi Inoue and Colin Reardon and Ana Marques and Jennifer Silvester and Maureen A Cox and Andrew C Wakeham and Omer H. Yilmaz and David M. Sabatini and Johan H. van Es and Hans Clevers and Toshiro Sato and Tak W Mak},
  journal={Cell stem cell},
  year={2016},
  volume={19 2},
  pages={
          205-216
        }
}
The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling via c-Myc. Mule also regulates protein levels of the receptor tyrosine kinase EphB3 by targeting it for proteasomal and lysosomal degradation. In the intestine, EphB/ephrinB interactions position cells along the crypt-villus axis and… CONTINUE READING
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E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2017
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