Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models

@article{Kim2010MulberryFP,
  title={Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models},
  author={Hyo Geun Kim and Mi Sun Ju and Jin Sup Shim and Min Cheol Kim and Sang-Hun Lee and Youngbuhm Huh and Sun Yeou Kim and Myung Sook Oh},
  journal={British Journal of Nutrition},
  year={2010},
  volume={104},
  pages={8 - 16}
}
Parkinson's disease (PD), one of the most common neurodegenerative disorders, is characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) to the striatum (ST), and involves oxidative stress. [] Key Result In SH-SY5Y cells stressed with 6-hydroxydopamine (6-OHDA), ME significantly protected the cells from neurotoxicity in a dose-dependent manner.

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It is shown that JSE treatment suppressed ROS and nitric oxide productions triggered by MPP+ in primary mesencephalic cells and inhibited depletion of striatal DA and its metabolites in vivo that resulted in significant improvement in PD-like movement impairment.

Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP-induced Parkinson's disease models in vitro and in vivo

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Results suggest a neuroprotective effect of BCA due to its high antioxidant and antiapoptotic activity, along with the absence of cytotoxicity.

Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson's disease.

  • Hyo Geun KimG. Park M. Oh
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    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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Recent Updates in Redox Regulation and Free Radical Scavenging Effects by Herbal Products in Experimental Models of Parkinson’s Disease

Several herbal products are beneficial for maintaining nerve cell function and for treating various neurodegenerative disorders by reducing oxidative stress by regulation of redox status and ROS inhibition in toxin-induced PD models.
...

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