Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models

  title={Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models},
  author={Hyo Geun Kim and Mi Sun Ju and Jin Sup Shim and Min Cheol Kim and Sang-Hun Lee and Youngbuhm Huh and Sun Yeou Kim and Myung Sook Oh},
  journal={British Journal of Nutrition},
  pages={8 - 16}
Parkinson's disease (PD), one of the most common neurodegenerative disorders, is characterised by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) to the striatum (ST), and involves oxidative stress. [] Key Result In SH-SY5Y cells stressed with 6-hydroxydopamine (6-OHDA), ME significantly protected the cells from neurotoxicity in a dose-dependent manner.

In Vitro and in Vivo Neuroprotective Effects of Walnut (Juglandis Semen) in Models of Parkinson’s Disease

It is shown that JSE treatment suppressed ROS and nitric oxide productions triggered by MPP+ in primary mesencephalic cells and inhibited depletion of striatal DA and its metabolites in vivo that resulted in significant improvement in PD-like movement impairment.

Proanthocyanidins exert a neuroprotective effect via ROS/JNK signaling in MPTP-induced Parkinson's disease models in vitro and in vivo

Investigating the protective effects and underlying mechanisms of PCs in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model revealed that PCs may exert neuroprotective effects in in vivo and in vitro PD models, and may have potential in the prevention or treatment of PD.

Black carrot anthocyanins exhibit neuroprotective effects against MPP+ induced cell death and cytotoxicity via inhibition of oxidative stress mediated apoptosis

Results suggest a neuroprotective effect of BCA due to its high antioxidant and antiapoptotic activity, along with the absence of cytotoxicity.

Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson's disease.

  • Hyo Geun KimG. Park M. Oh
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2014

Recent Updates in Redox Regulation and Free Radical Scavenging Effects by Herbal Products in Experimental Models of Parkinson’s Disease

Several herbal products are beneficial for maintaining nerve cell function and for treating various neurodegenerative disorders by reducing oxidative stress by regulation of redox status and ROS inhibition in toxin-induced PD models.



Protective effects of green tea polyphenols and their major component, (–)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells

The notion that green tea polyphenols have the potential to be effective as neuropreventive agents for the treatment of neurodegenerative diseases is supported.

Neuroprotective Strategies in Parkinson’s Disease

In spite of the extensive studies performed on postmortem substantia nigra from Parkinson’s disease patients, these studies have demonstrated that, at the time of death, a cascade of events had been initiated that may contribute to the demise of the melanin-containing nigro-striatal dopamine neurons.

Neurochemical findings in the MPTP model of Parkinson's disease

The knowledge about the neurotoxic mechanisms of MPTP such as mitochondrial dysfunction with breakdown of energy metabolism and free radical production will help to understand the underlying mechanisms of PD, which are not fully understood yet.

Berry fruit supplementation and the aging brain.

The benefits of interventions to retard or reverse age-related neuronal deficits, as well as their subsequent behavioral manifestations, in rodent models are discussed and the putative molecular mechanisms involved in their benefits are described.

Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits

Phytochemicals present in antioxidant-rich foods such as spinach may be beneficial in retarding functional age-related CNS and cognitive behavioral deficits and, perhaps, may have some benefit in neurodegenerative disease.

Fruit Polyphenolics and Brain Aging

The results indicate that increasing dietary intake of fruits and vegetables high in antioxidant activity may be an important component of a healthy living strategy designed to maximize neuronal and cognitive functioning into old age.

MPTP: a review of its mechanisms of neurotoxicity

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease.

Results indicate that parkin gene therapy may represent a promising candidate treatment for PD, with significant reductions in alpha-synuclein-induced neuropathology, and a key role for parkin in the genesis of Lewy bodies.