Muir-Torre Syndrome and Central Nervous System Malignancy: Highlighting an Uncommon Association.

@article{Kurtzman2015MuirTorreSA,
  title={Muir-Torre Syndrome and Central Nervous System Malignancy: Highlighting an Uncommon Association.},
  author={D J B Kurtzman and Andrew J Fabiano and Jingxin Qiu and Nathalie Charlotte Zeitouni},
  journal={Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]},
  year={2015},
  volume={41 7},
  pages={856-9}
}
Muir–Torre syndrome (MTS) is an uncommon cancer syndrome characterized by the development of cutaneous and visceral neoplasms. The majority of cases are familial exhibiting an autosomal dominant inheritance pattern and occur as a result of germline mutations involving the mismatch repair (MMR) genesMSH2,MLH1,MSH6, or PMS2. These mutations produce microsatellite instability that eventuates in tissue carcinogenesis. Sporadic MTS is rare and is distinguished from the heritable form by the… CONTINUE READING

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