Mucus secretion by single tracheal submucosal glands from normal and cystic fibrosis transmembrane conductance regulator knockout mice.

@article{Ianowski2007MucusSB,
  title={Mucus secretion by single tracheal submucosal glands from normal and cystic fibrosis transmembrane conductance regulator knockout mice.},
  author={Juan P. Ianowski and Jae Young Choi and Jeffrey J. Wine and John W. Hanrahan},
  journal={The Journal of physiology},
  year={2007},
  volume={580 Pt 1},
  pages={301-14}
}
Submucosal glands line the cartilaginous airways and produce most of the antimicrobial mucus that keeps the airways sterile. The glands are defective in cystic fibrosis (CF), but how this impacts airway health remains uncertain. Although most CF mouse strains exhibit mild airway defects, those with the C57Bl/6 genetic background have increased airway pathology and susceptibility to Pseudomonas. Thus, they offer the possibility of studying whether, and if so how, abnormal submucosal gland… CONTINUE READING

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