Mucosal vaccination delays or prevents prion infection via an oral route

@article{Goi2005MucosalVD,
  title={Mucosal vaccination delays or prevents prion infection via an oral route},
  author={Fernando Go{\~n}i and Elin Knudsen and Fernanda Schreiber and Henrieta Scholtzova and Joanna E. Pankiewicz and Richard I. Carp and Harry C. Meeker and Richard Rubenstein and D. Brown and Man Sun Sy and Jos{\'e} Alejandro Chabalgoity and Einar M. Sigurdsson and Thomas M. Wisniewski},
  journal={Neuroscience},
  year={2005},
  volume={133},
  pages={413-421}
}
In recent years major outbreaks of prion disease linked to oral exposure of the prion agent have occurred in animal and human populations. These disorders are associated with a conformational change of a normal protein, PrP(C) (prion protein cellular), to a toxic and infectious form, PrP(Sc) (prion protein scrapie). None of the prionoses currently have an effective treatment. A limited number of active immunization approaches have been shown to slightly prolong the incubation period of prion… Expand

Paper Mentions

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Could immunomodulation be used to prevent prion diseases?
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