Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats.

@article{Satoh2014MucosalPA,
  title={Mucosal protective agents prevent exacerbation of NSAID-induced small intestinal lesions caused by antisecretory drugs in rats.},
  author={Hiroshi Satoh and Kikuko Amagase and Koji Takeuchi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2014},
  volume={348 2},
  pages={227-35}
}
Antisecretory drugs such as histamine H₂-receptor antagonists and proton pump inhibitors are commonly used for the treatment of upper gastrointestinal mucosal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs). However, it has recently been reported that these drugs exacerbate NSAID-induced small intestinal lesions in rats. Unfortunately, there are few effective agents for the treatment of this complication. We examined the effects of mucosal protective agents (MPAs) (misoprostol… CONTINUE READING
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