Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.

@article{Robinson2008MucosalPB,
  title={Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.},
  author={Andreas Robinson and Simon Keely and J{\"o}rn Karhausen and Mark E. Gerich and Glenn T Furuta and Sean P Colgan},
  journal={Gastroenterology},
  year={2008},
  volume={134 1},
  pages={145-55}
}
BACKGROUND & AIMS A number of recent studies have implicated tissue hypoxia in both acute and chronic inflammatory diseases, particularly as they relate to mucosal surfaces lined by epithelial cells. In this context, a protective role for the transcriptional regulator hypoxia-inducible factor (HIF) was shown through conditional deletion of epithelial HIF-1alpha in a murine model of colitis. Here, we hypothesized that pharmacologic activation of HIF would similarly provide a protective… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 42 references

HIF - dependent induction of adenosine A 2 B receptors in hypoxia

NA Louis, KE Hamilton, T Kong, SP Colgan
FASEB J • 2006

Recent advances in erythropoietic agents in renal anemia

EJ Soilleux, H Turley, +3 authors AL Harris
Semin Nephrol • 2006

HIF-dependent induction of apical CD55 coordinates epithelial clearance of neutrophils.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2005

Hypoxia - inducible factor 1 alpha and vascular endothelial growth factor overexpression in ischemic colitis

J Wang, YX Fu
World J Gastroenterol • 2005

Tumor necrosis factor family members and inflammatory bowel disease

Suski, D Zabel, V Levin, H Scheuenstuhl, TK Hunt
Immunol Rev • 2005

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