Mucosal peptide hydrolase and brush-border marker enzyme activities in three regions of the small intestine of rats with experimental uraemia.

@article{Haines1990MucosalPH,
  title={Mucosal peptide hydrolase and brush-border marker enzyme activities in three regions of the small intestine of rats with experimental uraemia.},
  author={D J Haines and Charles H. Swan and J. Russell Green and John F. Woodley},
  journal={Clinical science},
  year={1990},
  volume={79 6},
  pages={
          663-8
        }
}
1. The activities of nine peptide hydrolases and three non-peptidase brush-border marker enzymes have been quantified in crude homogenates prepared from the proximal, mild and distal regions of small-intestinal mucosa for sham-operated (n = 9) and uraemic (n = 14) rats. Abnormalities in enzyme activities were observed in all regions studied in the uraemic group, although no reduction in food intake occurred. 2. The proximal region of the small intestine from uraemic rats showed a general fall… 

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References

SHOWING 1-10 OF 29 REFERENCES

Intestinal enzyme adaptation to normal diets of different composition.

TLDR
Different macromolecular nutrients were associated with adaptive differences in intestinal enzyme activities, which were biologically appropriate and coordinated with similar known changes in pancreatic and other enzyme activities concerned with assimilation of the particular food.

Small intestinal dipeptidases and disaccharidases in uraemic rats on a low protein diet.

TLDR
It is suggested that the changes of the intestinal dipeptidase activities in uraemia are adaptive to variation in the luminal content of di- and oligopeptides because of the type of nutrition given.

Morphology, dipeptidases and disaccharidases of small intestinal mucosa in chronic renal failure.

TLDR
Findings signify that a disturbed function of the small intestine is not uncommon in patients with CRF, and may be of importance when interpreting symptoms from the gut, especially when a carbohydrate-rich diet is given.

Activities of intestinal enzymes in experimental chronic renal insufficiency.

TLDR
Rats with chronic uremia following five-sixths nephrectomy showed a significant fall in the sucrase and maltase activities in the small intestinal mucosa, the lactase and cellobiase activities remained uninfluenced, while the activities of seven other dipeptidases studied were unaffected.

Intestinal Transport of Glucose and Amino Acids in Experimental Uremia

TLDR
The alterations in jejunal transport were associated with a decreased incorporation of [3H]phenylalanine into protein in the cell membrane-rich portion of intestinal mucosal scrapings and an alteration of the integrity of the jeJunal mucosa in uremia which affects its permeability and alters the transport of nutrient.

Small intestinal dipeptidases and disaccharidases in experimental uremia in rats.

TLDR
A highly significant increase in glycyl-L-leucine and L-methionyl- L-Methionine dipeptidases was found in uremic rats compared with controls and disaccharidase activities showed a slight increase in sucrase in u Remic rats.

Small intestinal absorption of glycine and glycyl-glycine in patients with chronic renal failure.

TLDR
Generally these results agree with those in earlier studies of non-uremic man showing that, in small intestine, dipeptides are taken up better and by a different mechanism than amino acids.

Analytical subcellular fractionation of jejunal biopsy specimens: methodology and characterization of the organelles in normal tissue.

  • T. Peters
  • Biology
    Clinical science and molecular medicine
  • 1976
TLDR
At least three distinct populations of lysosomes with different modal densities and enzyme content were demonstrated and this analytical fraction technique can be used to study the subcellular pathology of human jejunum.