Mucosal immunology of tolerance and allergy in the gastrointestinal tract.

@article{Steele2012MucosalIO,
  title={Mucosal immunology of tolerance and allergy in the gastrointestinal tract.},
  author={Lauren Steele and Lloyd Hitoshi Mayer and M Cecilia Berin},
  journal={Immunologic research},
  year={2012},
  volume={54 1-3},
  pages={75-82}
}
The mucosal immune system typically exists in a state of active tolerance to food antigens and commensal bacteria. Tolerance to food proteins is induced in part by dendritic cells residing in the intestinal mucosa and implemented by regulatory T cells. Food allergy occurs when immune tolerance is disrupted and a sensitizing immune response characterized by food-specific IgE production occurs instead. Experimental food allergy in mice requires use of adjuvant or exploitation of alternate routes… CONTINUE READING
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