Mucosal immunization with recombinant influenza hemagglutinin protein and poly gamma-glutamate/chitosan nanoparticles induces protection against highly pathogenic influenza A virus.

@article{Moon2012MucosalIW,
  title={Mucosal immunization with recombinant influenza hemagglutinin protein and poly gamma-glutamate/chitosan nanoparticles induces protection against highly pathogenic influenza A virus.},
  author={Ho-Jin Moon and Jong-Soo Lee and Melbourne Rio Talactac and Mohammed Y. E. Chowdhury and Jae-Hoon Kim and Min-Eun Park and Young Ki Choi and M. -H. Sung and C. Kim},
  journal={Veterinary microbiology},
  year={2012},
  volume={160 3-4},
  pages={277-89}
}
Intranasal administration of recombinant influenza hemagglutinin (rHA) antigen or inactivated virus with nanoparticles (NPs) composed of poly-γ-glutamic acid (γ-PGA) and chitosan which are safe, natural materials, and able to target the mucosal membrane as a mucosal adjuvant, could induce a high degree of protective mucosal immunity in the respiratory tract. Intranasal immunization with mixture of rHA antigen or inactivated virus and γ-PGA/chitosan nanoparticles (PC NPs) induced not only a high… CONTINUE READING
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