Mucosal immunization with inactivated HIV-1-capturing nanospheres induces a significant HIV-1-specific vaginal antibody response in mice.

@article{Akagi2003MucosalIW,
  title={Mucosal immunization with inactivated HIV-1-capturing nanospheres induces a significant HIV-1-specific vaginal antibody response in mice.},
  author={Takami Akagi and Masaki Kawamura and Masamichi Ueno and Katsuya Hiraishi and Masakazu Adachi and Takeshi Serizawa and Mitsuru Akashi and Masanori Baba},
  journal={Journal of medical virology},
  year={2003},
  volume={69 2},
  pages={163-72}
}
Mucosal secretory IgA is considered to have an important role in the prevention of human immunodeficiency virus type 1 (HIV-1) transmission through sexual intercourse. Therefore, substances that induce HIV-1-specific IgA antibody in the genital tract may become promising candidates for prophylactic vaccine against HIV-1 infection. We have previously reported that concanavalin A-immobilized polystyrene nanospheres (Con A-NS) could efficiently capture HIV-1 particles and gp120 antigens on their… CONTINUE READING

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