Mucosal immunization with a urease B DNA vaccine induces innate and cellular immune responses against Helicobacter pylori.

@article{Hatzifoti2006MucosalIW,
  title={Mucosal immunization with a urease B DNA vaccine induces innate and cellular immune responses against Helicobacter pylori.},
  author={Caterina Hatzifoti and Yvonne Roussel and Andrew G Harris and Brendan W. Wren and John W Morrow and Mona Bajaj-Elliott},
  journal={Helicobacter},
  year={2006},
  volume={11 2},
  pages={113-22}
}
BACKGROUND Helicobacter pylori is recognized as a major risk factor for recurrent gastroduodenal inflammatory diseases and gastric adenocarcinoma. The high prevalence of H. pylori infection worldwide, the risks of side-effects from antibiotic therapy, and increasing resistance to antibiotics are the main primers for the development of improved H. pylori vaccines. The antigenic potential of its urease enzyme, a critical virulence factor required for colonization of the gastric mucosa, has been… CONTINUE READING
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