Mucosal immunity and tolerance: relevance to vaccine development.

  title={Mucosal immunity and tolerance: relevance to vaccine development.},
  author={C{\'e}cil Czerkinsky and Fabienne Anju{\`e}re and Jerry R. Mcghee and Annie George-Chandy and Jan Holmgren and Marie Paule Kieny and K Fujiyashi and Jiri F. Mestecky and Val{\'e}rie Pierrefite-Carle and Carola Rask and Jia-bin Sun},
  journal={Immunological reviews},
The mucosal immune system of mammals consists of an integrated network of lymphoid cells which work in concert with innate host factors to promote host defense. Major mucosal effector immune mechanisms include secretory antibodies, largely of immunoglobulin A (IgA) isotype, cytotoxic T cells, as well as cytokines, chemokines and their receptors. Immunologic unresponsiveness (tolerance) is a key feature of the mucosal immune system, and deliberate vaccination or natural immunization by a mucosal… CONTINUE READING


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