Mucosal co-immunization of mice with recombinant lactococci secreting VapA antigen and leptin elicits a protective immune response against Rhodococcus equi infection.

@article{Cauchard2011MucosalCO,
  title={Mucosal co-immunization of mice with recombinant lactococci secreting VapA antigen and leptin elicits a protective immune response against Rhodococcus equi infection.},
  author={S{\'e}verine Cauchard and Luis Gilberto Berm{\'u}dez-Humar{\'a}n and S{\'e}bastien Blugeon and Christelle Laugier and Philippe Langella and Julien Cauchard},
  journal={Vaccine},
  year={2011},
  volume={30 1},
  pages={95-102}
}
Rhodococcus equi causes severe pneumonia in foals and has recently gained attention as a significant opportunistic pathogen in immunocompromised humans. However, no effective vaccine to prevent rhodococcosis is currently available. In this study, we have engineered the food-grade bacterium Lactococcus lactis to secrete the virulence-associated protein A from R. equi (LL-VapA). The immunogenic potential of LL-VapA strain was then evaluated after either intragastric or intranasal immunization in… CONTINUE READING