Mucosal and systemic immunizations with killed Pseudomonas aeruginosa protect against acute respiratory infection in rats.

@article{Cripps1994MucosalAS,
  title={Mucosal and systemic immunizations with killed Pseudomonas aeruginosa protect against acute respiratory infection in rats.},
  author={Allan Cripps and Margaret L. Dunkley and Robert L. Clancy},
  journal={Infection and immunity},
  year={1994},
  volume={62 4},
  pages={1427-36}
}
The aim of this study was to determine the efficacies of prior mucosal (oral, intra-Peyer's patch, or intratracheal) and systemic (subcutaneous) immunizations with killed Pseudomonas aeruginosa in clearance of an acute P. aeruginosa respiratory infection in rats. Rats were immunized with paraformaldehyde-killed P. aeruginosa at various doses, and 2 weeks later, the rats were challenged with a log10 dose of 8.7 live bacteria. This dose was fatal for unimmunized rats, with death occurring… CONTINUE READING

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