Mucosal and systemic immunity in mice after intranasal immunization with recombinant Lactococcus lactis expressing ORF6 of PRRSV.

@article{Wang2014MucosalAS,
  title={Mucosal and systemic immunity in mice after intranasal immunization with recombinant Lactococcus lactis expressing ORF6 of PRRSV.},
  author={Zhenhua Wang and Xiao-han Cao and Xiao-gang Du and Hai-bo Feng and Di-Wang and He-Song and Xian-yin Zeng},
  journal={Cellular immunology},
  year={2014},
  volume={287 2},
  pages={
          69-73
        }
}
The purpose of the study was to construct mucosal vaccine of a recombinant Lactococcus lactis expressing PRRSV ORF6 gene and evaluate mucosal and systemic immune response against PRRSV in mice after intranasal immunization. The result show that the vaccine can stimulate mice to produce specific IgG in serum and remarkable special s-IgA in lung lavage fluid, at the same time, the contents of cytokines IL-2 and IFN-γ of the experimental group were significant higher than those of the control… CONTINUE READING
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