Mucosal and systemic immune responses induced after oral delivery of vaccinia virus recombinants.

@article{Gherardi1999MucosalAS,
  title={Mucosal and systemic immune responses induced after oral delivery of vaccinia virus recombinants.},
  author={Mar{\'i}a Magdalena Gherardi and M Carmen Desco Esteban},
  journal={Vaccine},
  year={1999},
  volume={17 9-10},
  pages={1074-83}
}
The immune responses elicited after oral delivery of vaccinia virus (VV) recombinants are not well defined. In this study we show with mice, that after oral administration of a VV recombinant expressing the luciferase reporter gene, VV gene expression takes place for several days in gut-associated lymphoid (GALT) tissues as well as in the spleen. After 14 days, a significant mucosal IgA response against VV was detected in vaginal and intestinal washings, as well as a systemic specific IgG… CONTINUE READING