Mucosal and peripheral Lin- HLA-DR+ CD11c/123- CD13+ CD14- mononuclear cells are preferentially infected during acute simian immunodeficiency virus infection.

@article{Moore2012MucosalAP,
  title={Mucosal and peripheral Lin- HLA-DR+ CD11c/123- CD13+ CD14- mononuclear cells are preferentially infected during acute simian immunodeficiency virus infection.},
  author={Andrew C. Moore and Sandra L. Bixler and Mark G. Lewis and Daniela Verthelyi and Joseph J Mattapallil},
  journal={Journal of virology},
  year={2012},
  volume={86 2},
  pages={1069-78}
}
Massive infection of memory CD4 T cells is a hallmark of early simian immunodeficiency virus (SIV) infection, with viral infection peaking at day 10 postinfection (p.i.), when a majority of memory CD4 T cells in mucosal and peripheral tissues are infected. It is not clear if mononuclear cells from the monocyte and macrophage lineages are similarly infected during this early phase of explosive HIV and SIV infections. Here we show that, at day 10 p.i., Lin(-) HLA-DR(+) CD11c/123(-) CD13(+) CD14… CONTINUE READING
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CD4 memory T cells harbor most Th-17 cells and are preferentially infected during acute SIV infection

  • M Kader
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  • 2009
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