Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency.

@article{Assogba2007MucosalAO,
  title={Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency.},
  author={Barnabe Dossou Assogba and Sarah Leavell and Kyle Porter and Mary Jo Burkhard},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={195 8},
  pages={1184-8}
}
Human immunodeficiency virus type 1 can occasionally be detected as a cryptic or latent infection in seronegative, asymptomatic patients. To develop an animal model of host latency, cats were mucosally challenged with 10(2)-10(6) feline immunodeficiency virus (FIV)-infected T cells. Although high-dose exposure (10(4)-10(6) T cells) resulted in progressive infection, no evidence of infection was seen in 5 of 6 cats exposed to 10(2) or 10(3) T cells. However, after ex vivo CD8(+) T cell depletion… CONTINUE READING
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