Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes.

  title={Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes.},
  author={Anthony J. Slavin and Ruth Maron and Howard L. Weiner},
  journal={International immunology},
  volume={13 6},
IL-10 is an immunoregulatory cytokine that can modulate immune processes, inhibiting the expression of inflammatory T(h)1 type responses as well as affecting antigen-presenting cell function. In addition, IL-10 has been shown to be active at mucosal surfaces. In the present study, we examined the role of IL-10 on orally and nasally induced tolerance. Treatment of (PL/J x SJL)F(1) mice with low-dose oral myelin basic protein (MBP) (0.5 mg) and simultaneous oral IL-10 given 3 times reduced the… CONTINUE READING
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