Mucosal adjuvant activity of oligomannose-coated liposomes for nasal immunization

@article{Ishii2009MucosalAA,
  title={Mucosal adjuvant activity of oligomannose-coated liposomes for nasal immunization},
  author={Mariko Ishii and Naoya Kojima},
  journal={Glycoconjugate Journal},
  year={2009},
  volume={27},
  pages={115-123}
}
In the present study, we investigated the effectiveness of liposomes coated with a neoglycolipid consisting of mannotriose and dipalmitoylphosphatidylcholine (Man3-DPPE) as an adjuvant for induction of mucosal immunity. Immunization of BALB/c mice with ovalbumin (OVA)-encapsulated Man3-DPPE-coated liposomes (oligomannose-coated liposomes; OMLs) by a nasal route produced high levels of OVA-specific IgG and IgA antibodies in serum of immunized mice 1 week after the last nasal immunization… CONTINUE READING

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