Mucosal addressin is required for the development of diabetes in nonobese diabetic mice.

@article{Hnninen1998MucosalAI,
  title={Mucosal addressin is required for the development of diabetes in nonobese diabetic mice.},
  author={Arno L. M. H{\"a}nninen and Ilkka Jaakkola and Sirpa Jalkanen},
  journal={Journal of immunology},
  year={1998},
  volume={160 12},
  pages={6018-25}
}
Immune responses are best initiated in the environment of lymphoid tissues wherein circulating lymphocytes enter by interacting with endothelial adhesion molecules. In type 1 diabetes, immune responses against pancreatic islets develop, but the environment in which this occurs remains unidentified. To determine whether lymphocyte homing to lymphoid organs is involved in the pathogenesis of diabetes in nonobese diabetic (NOD) mice, we blocked the function of the mucosal addressin cell adhesion… CONTINUE READING
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The NOD mouse: a model for analyzing the interplay between heredity and environment in development of autoimmune disease

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