Mucosal Lesions Induced in the Rat Intestinal Tract by the Anti-Inflammatory Drug, Wy-41,770, a Weak Inhibitor of Prostaglandin Synthesis, Contrasted with Those from the Potent Prostaglandin Inhibitor, Indomethacin

@article{Rainsford1988MucosalLI,
  title={Mucosal Lesions Induced in the Rat Intestinal Tract by the Anti-Inflammatory Drug, Wy-41,770, a Weak Inhibitor of Prostaglandin Synthesis, Contrasted with Those from the Potent Prostaglandin Inhibitor, Indomethacin},
  author={K. Rainsford},
  journal={Toxicologic Pathology},
  year={1988},
  volume={16},
  pages={366 - 375}
}
  • K. Rainsford
  • Published 1988
  • Biology, Medicine
  • Toxicologic Pathology
The intestinal ulcerogenic activity of the weak prostaglandin synthesis inhibitor drug Wy-41,770 [5H-dibenzo(a,d)-cyclohepten-5-ylidine] was contrasted with the potent synthesis inhibitor, indomethacin, in rats to establish the relationship of inhibition of prostaglandin synthesis to the intestinal damage. Wy-41,770 induced superficial erosions only in the cecum 26 hr after a single oral dose of 250 or 500 mg/kg of the drug, progressing to ulcers after 5 days dosing with ultrastructural… Expand
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