Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease

@article{Basson2016MucosalIB,
  title={Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease},
  author={Abigail Raffner Basson and Ashley Trotter and Alexander Rodriguez-Palacios and Fabio Cominelli},
  journal={Frontiers in Immunology},
  year={2016},
  volume={7}
}
Numerous reviews have discussed gut microbiota composition changes during inflammatory bowel diseases (IBD), particularly Crohn’s disease (CD). However, most studies address the observed effects by focusing on studying the univariate connection between disease and dietary-induced alterations to gut microbiota composition. The possibility that these effects may reflect a number of other interconnected (i.e., pantropic) mechanisms, activated in parallel, particularly concerning various bacterial… 
Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome
TLDR
Four therapeutic strategies – probiotics, prebiotics, vitamin D and caloric restriction – that have the potential to improve and add to current IBD treatment regimens are highlighted.
Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis
TLDR
Diet might influence gut microbiota composition and activity, SCFAs production, and metabolic effects, as well as modulate several metabolic pathways and are involved in obesity, insulin resistance, and type 2 diabetes.
Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
TLDR
How different dietary patterns affect microbial populations in the gut is described and the subsequent impact of bacterial products and metabolites on molecular pathways of cancer development is illustrated, both locally in the Gut and systemically in distant organs.
Gut microbiome: pertinence in fibromyalgia.
TLDR
These are merely the first steps in understanding the role of the gut microbiome in chronic pain and specifically FM, one might envision exciting future perspectives for better mechanistic understanding of FM, for the development of objective diagnostic aids and potentially for new therapeutic modalities.
Probiotics Interact With Lipids Metabolism and Affect Gut Health
TLDR
It is found that different lipids and their derivatives have different effects on IBD and gut microbes, which provides the possibility to explore the role of probiotics in improving gut health.
A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions
TLDR
Dietary regimes enriched in polyphenols may efficiently support IBD remission affecting the intestinal dysbiosis, suggesting that polyphenol-enriched diets may create unfavorable conditions for distinct bacterial species.
Microbial Factors in Inflammatory Diseases and Cancers.
  • H. Ong, H. Yim
  • Biology, Medicine
    Advances in experimental medicine and biology
  • 2017
TLDR
How each microbial factor can contribute in the manifestation of many diseases such as cancers, Inflammatory Bowel Diseases, obesity, type-2 diabetes, non-alcoholic fatty liver diseases, nonalcoholic steatohepatitis, and cardiovascular diseases is highlighted.
Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?
TLDR
A large body of evidence point to succinate as a new strategic mediator in the microbiota-host cross-talk, which might provide the basis for new therapeutically approaches in a near future.
Vitamin D Axis in Inflammatory Bowel Diseases: Role, Current Uses and Future Perspectives
TLDR
The role of the vitamin D axis in immune-mediated diseases, with particular emphasis on its interplay with the gut microbiome in the pathogenesis of IBD is explored, including optimizing VDR function both with vitamin D analogues and probiotics.
...
...

References

SHOWING 1-10 OF 683 REFERENCES
The Influence of the Gut Microbiome on Obesity, Metabolic Syndrome and Gastrointestinal Disease
TLDR
The role of Gut microbiota maintenance/alterations of gut microbiota as a significant factor as asignificant factor discriminating between health and common diseases is reviewed.
Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases
The composite human gut microbiomes of Western populations have changed over the past century, brought on by new environmental triggers that often have a negative impact on human health. Diets high
Functional Impacts of the Intestinal Microbiome in the Pathogenesis of Inflammatory Bowel Disease
TLDR
Functional analyses of the microbiome may be the key to understanding the role of microbiota in the development and chronicity of IBD and reveal new strategies for therapeutic intervention.
The gut microbiota and inflammatory bowel disease
TLDR
A number of trials have shown that therapies correcting dysbiosis, including fecal microbiota transplantation and probiotics, are promising in IBD, and it has not yet been established how Dysbiosis contributes to intestinal inflammation.
Gut microbiota and metabolic syndrome.
TLDR
Manipulation of gut microbiota through the administration of prebiotics or probiotics could reduce intestinal low grade inflammation and improve gut barrier integrity, thus, ameliorating metabolic balance and promoting weight loss.
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
TLDR
Results support the emerging concept that perturbed host–microbiota interactions resulting in low-grade inflammation can promote adiposity and its associated metabolic effects and suggest that the broad use of emulsifying agents might be contributing to an increased societal incidence of obesity/metabolic syndrome and other chronic inflammatory diseases.
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
TLDR
The microbiome of ileal Crohn's disease was notable for increases in virulence and secretion pathways, and the first insights into community-wide microbial processes and pathways that underpin IBD pathogenesis are provided.
Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review
TLDR
This review article presents possible pathways of polyphenol metabolism by intestinal bacteria and describes the diet-derived bioactive metabolites produced by gut microbiota, with a particular emphasis on polyphenols and their potential impact on human health.
Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice
TLDR
Diet has a dominating role in shaping gut microbiota and changes of some key populations may transform the gut microbiota of Wt animals into a pathogen-like entity relevant to development of MS, despite a complete host genome.
...
...